Abstract

Rani S. Kankate* ^1,2, Parag S. Gide² and Deepak P. Belsare³

DOI : http://dx.doi.org/10.13005/ojc/300446

Benzimidazole and piperazines are the important pharmacophores in the structures of many antifungal compounds. Further, the phenylmethanone are also a unique class of compounds whose antifungal profile is not much exploited. So to exploit their antifungal potential we have selected these three combinations and framed the novel parent structure for our research work. In this study a novel series of benzimidazoles derivatives was synthesized by microwave irradiation and characterized by ¹H NMR, ¹³C NMR, Infra Red (IR), and Mass Spectroscopy (MS), and by elemental analysis. The screening of compound for in vitro (turbidimetric method) antifungal activity against C.albicans revealed activity in many of the compounds as comparable to that of ketoconazole.

Antifungal activity; Benzimidazole; Piperazine and Lanosterol14-α-demethylase

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