Abstract

Cong Tien Nguyen*¹, Dao Thi Hong Dinh¹, Thin Van Nguyen², Giang Duc Le² and Hien Cao Nguyen³

DOI : http://dx.doi.org/10.13005/ojc/350245

4-Chlorobenzylidene-2-methyl-(4H)-oxazol-5-one, which were prepared from 4-chlorobenzaldehyde and acetylglycine in reaction with hydrazine hydrate in ethanol gave 1-amino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-one. However, treatment of 4-chlorobenzylidene-2-methyl-(4H)-oxazol-5-one with hydrazine hydrate in pyridine yielded 3-(4-chlorophenyl)propanohydrazide. Reaction of  1-amino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-one with aromatic aldehydes gave eight corresponding Schiff’s bases namely 1-arylideneamino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-ones. The structure of the 3-(4-chlorophenyl)propanohydrazide and the imidazoline-5-one compounds was confirmed by IR, ¹H-NMR and MS spectral data. The Schiff’s bases were tested for antimicrobial activities against several strains of Gram-positive, Gram-negative bacteria, molds and yeasts.

Antimicrobial Activities; 1-Amino-4-(4-Chlorobenzylidene)-2-Methyl-1H-Imidazolin-5(4H)-One; 4-Chlorobenzylidene-2-Methyl-(4H)-Oxazol-5-One; Schiff Bases; Spectral Data

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