Abstract

Farzaneh Hosseini¹, Mirabdullah Seyed Sadjadi ^1*, Nazanin Farhadyar²

DOI : http://dx.doi.org/10.13005/ojc/300420

Modified Fe₃O₄ nanoparticles with (3-aminopropyl) triethoxysilane (APTES) were synthesized by post grafting method for loading the anti-inflammatory drug: (+)-(S)-2-(6-methoxynaphthalen-2-yl) propanoic acid –Naproxen and (RS) 2-(3-benzoylphenyl)-propionic acid -Ketoprofen. The prepared samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FE-SEM), Energy Dispersive X-Ray Spectroscopy (EDX), Vibrating sample magnetometer (VSM), and Dynamic light scattering (DLS) diagrams. These nanoparticles have surface with free - NH₂ groups can carry out ionic interaction with carboxylic groups and act as a carrier of drugs.

Nanoparticle; Carrier; Drug delivery; Naproxen; Ketoprofen

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