Abstract

Balasaheb D. Kalyankar, Prashant N. Ubale and Sambhaji P. Vartale*

DOI : http://dx.doi.org/10.13005/ojc/300448

Guanidine hydrochloride (1) on treatment with bis(methylthio)methylene malonitrile (2) in N,N-dimethyl formamide (DMF) and  catalytic amount of anhydrous potassium carbonate gives diimino pyrimido pyrimidine (3). The later were further reacted with various substituted 2-amino benzothiazoles (4) to gives bis (diimino benzothiazolo pyrimido pyrimidines) (5a-g). All these synthesized compounds were screened for their antimicrobial activity.

Bis(methylthio)methylene malononitrile; Guanidine hydrochloride; N; N-dimethyl formamide (DMF) and Potassium carbonate

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