Abstract

Fadilah Fadilah^1,4, Ade Arsianti^1,4, Arry Yanuar², Retnosari Andrajati², Rafika Indah Paramita^1,4 and Ernie Hernawati Purwaningsih^3,4

DOI : http://dx.doi.org/10.13005/ojc/340558

A multivariate analysis of the quantitative relationship of antioxidant structure and activity of a series of benzoic acid derivatives based on computational chemical properties was calculated. The parameters were obtained from the optimized structure of ionization pKa and hydrophobic ClogP while the compound activity was obtained from the literature. Analysis of the relationship between antioxidant activity and chemical properties of the compound was performed with the SPSS 21 program. The analysis result gives the best equation model as follows: Log 1 / IC₅₀ = –1.514 + 0,516 log P + 0.087 pKa (n = 10 r = 0,962 SE = 0,301 Fcalc./Ftable = 1,422).

Antioxidant; Benzoic Acid Derivatives; QSAR

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