Abstract

K. P.Srivastava*, Anuradha Singh and Suresh Kumar Singh

DOI : http://dx.doi.org/10.13005/ojc/300339

A rapid, efficient, clean and environmentally benign exclusive synthesis of Schiff bases as new ligands and their complexes with Zn(II) have been developed using condensation of pyridoxalwith amoxicillin (L¹), cephalexin (L²), sulphamethoxazole (L³) and trimethoprim (L⁴) efficiently in analcoholic suspension medium using alkali catalyst with excellent yields under microwaves irradiation. This method provides several advantages such as environmental friendliness, simple work-up procedure, short reaction times, non-hazardous and excellent yield of products.The results are compared with conventional methods for their yield and reaction time. The Schiff base ligands and the complexes were characterized by micro-analytical, thermo-gravimetric, magnetic and spectroscopic studies.All the Schiff bases were bidentate (NO donor) ligands. All complexes were found to be six co-ordinate dihydrates and ML₂[1:2 (metal: ligand) ratio] type. The complexes are coloured and stable in air. All the complexes under investigation possess antibacterial activity. The antibacterial activity showed the following trend:

Schiff bases; Coordination compounds;Microwave irradiation; Antibacterial activity; Zinc

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