Abstract

Sruthy B¹, M. S. Latha²and Sherly P. Anand³

DOI : http://dx.doi.org/10.13005/ojc/340264

Bovine mastitis is an infection of cattle leading to a huge reduction in milk production that causes severe economic loss in dairy industry across the world. Causative of the disease includes bacteria, virus and non-bacterial pathogens. Among these, Staphalococus aureus is the common cause of mastitis and is highly resistant to the most routinely used antibiotics. So Current antibiotic  therapy has shown limited efficacy. The crude extract of locally available medicinal plant Boerhavia diffusa is used traditionally against mastitis and is found to be highly effective. The objective of the study is the identification of the  phytochemicals in Boeravia diffusa  responsible for the antimastitis activity by insilico docking analysis using Schrodinger Suit v 9.2. 20 phytochemicals in Boerhavia diffusa were selected for docking studies based on ADMET properties. The high resolution crystal structure of the target receptor protein of Staphalococus aureus was retrieved from PDB. Structure of the phytochemicals and the most commonly used antibiotic against Bovine mastitis were selected from PUB CHEM NCBI. The phytochemicals, Boeravinone A, B, C, D, E and F from Boehravia diffusa showed good docking scores and better interaction with the active sites of the target proteins used for the evaluation than the most commonly used commercially available drug. Results of this study are important for the designing of novel drugs for the treatment of mastitis.

Staphalococus Aureus Monofunctional Glycosyltransferase; Bovine Mastitis; Docking, Boerhavia Diffusa; Qik Prop

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