Abstract

Amira S. Eldin¹, Mona M. Abdel-Moety¹, Aliaa S. M. El-Tantawy¹, Abdalla Shalaby² and Magda El-Maamly²

DOI : http://dx.doi.org/10.13005/ojc/340240

The present study aimed to suggest a sensitive, precise and selective electrochemical approach for the potentiometric detection of Levofloxacin hydrochloride (LVX) and Daclatasvir dihydrochloride (DAC). The suggested technique was conducted by the incorporation of LVX or DAC with precipitating agent to construct two active sensors. Different concentration ranges of the investigated drugs (1.0 10^-5-1.0 10^-2 and 1.0 10^-6-1.0 10^-3 mol L^-1)were detected under optimum conditions and provided potentiometric responses of 58.7±0.2 and 28.7±0.5 mV decade^-1 with detection limits 3.2 10^-6 and 1.1 10^-7 for the two fabricated sensors, respectively. The fabricated LVX-TPB and DAC-TPB were successfully used for excellent detection of pure form and tablets of LVX and DAC.

Levofloxacin Hydrochloride; Daclatasvir Dihydrochloride; Plastic Membrane Sensors; Potentiometric Approach; Pharmaceutical Dosage Forms

[ View HTML Full Text]