ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Synthesis, Characterization and In Vitro Antitubercular and Antimicrobial Activities of new Aminothiophene Schiff Bases and Their Co(II), Ni(II), Cu(II) and Zn(II) Metal Complexes

Ganesh More1, Sakina Bootwala1, Sushma Shenoy2, Joyline Mascarenhas2 and K. Aruna2

DOI : http://dx.doi.org/10.13005/ojc/340225


Abstract:

Two new clinically active Schiff bases and their transition metal complexes were synthesized and studied by different spectroscopic and physicochemical methods like NMR, IR, UV-Visible, ESR, TGA, XRD, mass, elemental analysis, molar conductivity and magnetic character. Synthesized complexes and Schiff bases were assessed for invitro antituberculosis activity for Mycobacterium tuberculosis (ATCC–27294) and for antimicrobial activity against drug resistant ESBL (Extended Spectrum β-lactamase) and MBL (Metallo β-lactamase) producing microbial strains. The biological activity of Schiff base was found to improve in presence of transition metal ions. Among the studied metal complexes, copper complexes displayed superior biological activity against all of the microbial strains.

Keywords:

Schiff Bases; Antitubercular Activity; Antimicrobial Activity; Transition Metal Complex; 2-Aminothiophene

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