Abstract

N. Y. Sreedhar and S. Jayarama Raddy

Electrochemical reduction behaviour of chlordiazepoxide hydrochlroide has been studied by employing the advanced electrochemical techniques such as d. c. polarography, cyclic voltammetry, a. c polarography, differential pulse polarography, millicoulometry and controlled potential electrolysis in the supporting electrolytes of pH ranging from 2.0 to 12.0. Kinetic parameters such as diffusion coefficient (D), forward rate constant (K°f, h) values are evaluated and the reduction mechanism is proposed on the basis of the results obtained. A differential pulse pola-rographic method is developed for the quantitative determination of chlordiazepoxide hydlride in pharmaceutical formulations.

Determination; Chlordiazepoxide

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