Abstract

Alka Pradhan, Vinod Pradhan and V.S . Jolly

A series of new Pyrazolones and acid hydrazides have been synthesised. Reaction of ethyl acetoacetate or ethyl benzoy lacetate with diazotised 2/3/4-nitroaniline gave substituted (2/3/4-nitro phenylazo) acetic acid, ethylester. Treatment of esters with 2- [(N-substituted)-p-chloro anilido] acetohydrazide gave 1-[(N-substituted-p-chloroanilido)aceto)-3- methyl/phenyl-4(2/3/4-nitropheny lazo)-5-Pyrazolones. The compounds have been screened for their antibacterial activities against S. aureus and E.Coli and anticancer activities

Acetohydrazide; E.Coli; Anticancer; Treatment

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