Abstract

S. Hamdan*, H. Fauziah and F. B. H. Ahmad

The phase equilibria of water/Aerosol-OT/Tween 20/hydrocarbon systems were investigated to prepare alcohol-free microemulsions for potential use as earners an pharmaceutical applications. The alcohol-free microemulsions were readily formed at variable weight ratio of Aerosol -OT and/or Tween 20 with the hydrocarbon (n-decane and p-xylene) and water. The microemulsion region was found to be dependent not only on the surfactant ratios but also on the nature of the hydrocarbon. Microemulsions containing aromatic hydrocarbon (p-xylene) showed a more defined area compared to microemulsion with aliphatic hydrocarbon(n-decane).

Pharmaceuticals; microemulsion; surfactant; Aerosol-OT; Tween 20

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