Abstract

R. M. Kedar, N. N. Vidhale, M. M. Chincholkar

Five 3-aoyl flavanones (la-e) were prepared by reacting diketones with aldehydes in ethanol in presence of pipendine. Each of these flavanones was reacted with semicarbazide hydrochloride and hydrazine hydrate in ethanol in presence of little piperidine to afford the formation of 1 -carboxamido-3,5-diaryl-4-aroyl pyrazoline and 3,5-diaryl-4-aroyl pyrazoline respectively. Further, these compounds were subjected to antimicrobial tests against the test organisms. Escherichia coli, Staphylococcus aureus, Proteus vulgaris, Klebsiella pneumoniae, Salmonella typhii, Shigella dysentry and Proteus mirabilis. Their MIC values were determined. Pyrazolines containing dim ethy lam ino group as a substituent have been found to possess higher antimicrobial activity.

5-Trisubstituted; Pyrazounes; Antimicrobial; Antimicrobial; pyrazoline

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