Abstract

Design, Synthesis, and Anti-Inflammatory Activity of Novel Quinazolines

Said A. El-Feky, Mohd. Imran and Naira Nayeem

DOI : http://dx.doi.org/10.13005/ojc/330217

Abstract:

Several new fluorinated quinazolinone derivatives were prepared and evaluated for in vitro anti-inflammatory activity. The molecular modelling study was performed for compounds 4, 8, 9, 10 and 13. The tested compounds showed strong interactions at the COX-2 binding sites. Compounds 8, 13, 9, and 10 containing triazole, thiadiazole, and oxadiazole rings showed the highest in vitro anti-inflammatory activity and the best binding into the COX-2 binding site.

Keywords:

Design; Fluorinated quinazolinones; Molecular modelling study; in vitro anti-inflammatory activity

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