Abstract

Modeling of IC⁵⁰(5-LOX and COX) Activity of Phenol Derivatives Against Leukemia Cells

Sameer Dixit¹and Arun K Sikarwar²

DOI : http://dx.doi.org/10.13005/ojc/330266

Abstract:

Phenols derivatives show different inhibitory selectivities towards 5-LOX and COX and induce cell death in leukemia cell lines. For modeling of activity against Leukemia cell lines K562, HL-60, Raji, MOLT4, 32D, Leukocytes, NIH3T3 etc. of phenol derivatives we used three descriptors Mor20e, Mor04m and RDF045m. 5-LOX and COX Values of Bobels are used to build model for Predicted Activity for 5-LOX and COX.

Keywords:

5-LOX; COX; QSAR; QSPR; 3D MoRSE Descriptors; RDF Descriptors; IC50

[ View HTML Full Text]

Back to TOC