Abstract

Synthesis of Benzo[G]Quinoxaline-5,10-Dione Based Pyridine Derivatives and their Antimycobacterial Activity

Shiv Kumar¹, Nitin Kumar² and Sushma Drabu³

DOI : http://dx.doi.org/10.13005/ojc/330230

Abstract:

Thirteen new compounds belonging to series 2-amino-6-(5,10-dioxo-2,3-diphenyl-5,10-dihydrobenzo[g]quinoxalin-7-yl)-4-(substituted)phenylpyridine-3-carbonitrile (6a-m) were synthesized by multistep synthetic scheme. The newly synthesized compounds were screened for their antimycobacterial activity by L.J. Slope (Conventional) Method. Compound 6h with 4-N(CH₃)₂ group at phenyl ring of above mentioned position has been reported as most active antimycobacterial compound and compound 6k with 4-CH₃ substitution at phenyl above mentioned position has been reported as the least active antimycobacterial compound.

Keywords:

Quinoxaline; Benzo[g]quinoxaline-5,10-dione; Pyridine; Antimycobacterial

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