Abstract

Delaram Ahmadi¹, Azim Akbarzadeh², Mahdi Arjmand³ and Amir Heidarinasab⁴

DOI : http://dx.doi.org/10.13005/ojc/320610

Cancer is an extremely dangerous disease among humans.breast cancer is still mostfrequently form of cancerwithin women population. Oxaliplatin isaapoptotic effectual compound in order to treatment of cancer with cytotoxic side effects. Nanocarriers with specific physicochemical properties are able to reduce side effectsof anticancer drugs.Nanoliposomes as carrierare the promising systemfor cancer treatmen due to stability,high targetingproperties, better bioavailability,  slow‑releasing and low systemic toxicity. By using polyethylene glycol (PEG)canincrease blood- circulationtime of the drugwith decreased side effects and improved efficacy alsoPEGcanincreasepenetration to the the tumor tissue.In this investigation, oxaliplatin was loaded onto pegylated liposomes through reverse phase evaporation method. Profile of drug release were evaluated.Pegylatednanoliposomaloxaliplatinexhibited slow‑releasing potential in comparison to conventional formulations.  The morphology of particles in each field wasanalyzedbyscanning electron microscopy (SEM).Apoptosis  rate wasevaluatedin breast cancer cell lines MCF-7 and MDA-MB-231 by flow cytometry.Pegylatednanoliposomaloxaliplatinshowed a suitable impact on apoptosis of breast cancer cell lines MCF-7 and MDA-MB-231  . Thus, pegylatednanoliposomaloxaliplatin can  employ with low systemic toxicity  in order to treatment of  breastcancer.

Breast cancer; Oxaliplatin; Liposome; Polyethyleneglycol; Nanodrugdelivery

[ View HTML Full Text]