Abstract

A. V. V. N. K.  Sunil Kumar^1*, S. Vijaya Saradhi²,  C. Bala Sekaran³, and T. V. Reddy⁴

Doxofylline is a phosphodiesterase inhibitor used in the treatment of bronchial asthma, chronic obstructive pulmonary disease and chronic bronchitis. In this study two simple, sensitive, precise and accurate visible spectrophotometric methods (A and B) have been developed for the determination of doxofylline in bulk and in its dosage forms. Method A is based on the formation of yellow colored charge transfer complex between doxofylline as n-donor and iodine as σ-acceptor. Method B is based on the reaction of doxofylline with iron (III) and subsequent reaction with α, α'-bipyridyl in an acid medium to yield a red colored complex. The colored products are quantitated spectrophotometrically at 395 and 535 nm by methods A and B, respectively. The methods determine the cited drug in concentration ranges of 4-32 (method A) and 2-16 (method B) μg mL^-1. The optimum experimental conditions have been studied. The proposed methods were successfully applied to the determination of the doxofylline in pure and dosage forms with good accuracy and precision. The results were compared statistically with those given by the reported method.

Doxofylline, Iodine; α; α’ Bipyridyl; Spectrophotometric analysis

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