Abstract

S.A. Iqbal, Sibi Jose and Suman Malik

Metal complexes of manganese (II) and cobalt (II) have been synthesized with active hypoglycemic agent (glimepiride), an oral antidiabetic drug. The elemental analyses of the ligand as well as metal complexes indicate that complexes having 2:1 stoichiometry of the type (C₂₄H₃₄N₄O₅ S)₂ M.2H₂O, where M= Mn(II) and Co(II). The complexes have been characterized by IR spectra, electronic spectral and molar conductance data. Infrared spectral studies confirm the co-ordination of sulphonyl oxygen on one side and enolic oxygen attached from other side with the metal ion. On the basis of electronic spectral values the complexes are proposed to have octahedral geometry. The molar conductivity also reveals that the complexes are non-ionic in nature.

Glimepiride; Synthesis; Characterization; Metal Complexes; Infrared spectroscopy.

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