Abstract

M. H. Salunke, Z. A. Filmwala* and A. D. Kamble

2-Amino-3-phenyl-propionic acid hydrazide (APPAH) (1) has been prepared by reacting earlier reported compound 2-amino-3-phenyl-propionic acid methyl ester (APPAME) with hydrazine hydrate. Schiff base 2[(4-methoxy-bezylidene)-amino]-3-phenyl-propionic acid (4-methoxy-benzylidene)-hydrazide (MBAPPAMBH) (2) has been synthesized by reacting (1) with 4-methoxy benzaldehyde and its metal complexes with Fe(III), Co(II), Zn(II), Cd(II), Y(III), and In(III) have been prepared. The ligand and metal complexes were characterized on the basis of elemental analysis, IR, NMR spectral data, molar conductance, magnetic susceptibility measurement, thermal analysis (TGA/DTA). In vitro antibacterial and antifungal activities of all compounds were tested.

Synthesis; Schiff base; Fe(III); Co(II); Zn(II); Cd(II); Y(III); and In (III) complexes; Antibacterial and antifungal activities

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