Abstract

Mild and Efficient Synthesis of 3-Acyl-5-Hydroxybenzofurans Via Bismuth Chloride-Catalyzed Cycloaddition of Unactivated 1,4-Benzoquinones With 1,3-Dicarbonyl Compounds

A. Thirupathaiah^¹*, G. Venkateshwar Rao^² and S. Ramanna^²

Abstract:

A method to prepare a variety of substituted 3-acyl-5-hydroxybenzofurans efficiently that relies on bismuth chloride-catalyzed cycloaddition of unactivated 1,4-benzoquinones with 1,3-dicarbonyl compounds is reported. The reaction was shown to be operationally straightforward and proceeds expediently under mild conditions to give the corresponding products in good to excellent yields (up to 95%) and with complete regioselectivity.

Keywords:

BiCl3; cycloadiition; 1,4-benzoquinones; 1,3-dicarbonyl

[ View HTML Full Text]

Back to TOC