ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Development of New Spectrophotometric Methods for The Determination of Alfuzosin Hydrochloride in Bulk and Pharmaceutical Formulations

D. Ravi Kumar1, S.V. M. Vardhan2, D. Ramachandran3 and C. Rambabu4


Abstract:

Two simple and sensitive methods A and B for the spectrophotometric determination of Alfuzosin hydrochloride have been described. These methods are based on the formation of purple color and red- violet colored chromogens obtained when the drug was diazotized with nitrous acid followed by coupling with Phloroglucinol and Resorcinol, exhibiting lmax at 520 and 600 nm respectively. These methods obey Beer’s law in the concentration ranges of 4-20 and 2-10 μg/mL. These methods are highly reproducible and have been applied to a wide variety of pharmaceutical preparations.

Keywords:

Alfuzosin hydrochloride; chromogen; spectrophotometry

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