Abstract

Neeta A. Junghare, Madhuri P. Bhise, M. M. chincholkar and P. R. Bhise

3-Aroyl-6-methyl flavones (Ia-f) were allowed to react with hydrozine hydrochloride in DMSO containing piperidine to give the corresponding 3-2-hydroxyphenyl-5-methyphenyl)-4-aroyl 5-arylpyrazoles (IIa-f) Their structural assignments are based on elemental analysis, spectral data (ir, uv and nmr) and chemical properties. All these compounds were tested in vitro for their antimicrobial (antibacterial and antifungal) activity by disk diffusion against gram positive, gram negative bacteria and fungi. In some of the compounds the results are found to be encouraging.

3-(-Hydroxy-5-methylphenyl)-4-aroyl-5-arylpyrazole

[ View HTML Full Text]