Abstract

Esmaeil Biazar* and Khalil Pourshamsian

Thermo-sensitive hydrogels were prepared by graft copolymerization of Polyvenylalcohol and chitosan with N-Isopropylacrylamide via gamma radiation. Characterization of hydrogels such as DSC analysis and swelling and solubility tests in different ratios were investigated. DSC and solubility analysis showed chitosan and PVA and NIPAAm monomer were grafted via gamma radiation successfully. Results show swelling of samples increased with to PVA increasing. Swelling ratio and curves results administrated hydrophilicity / hydrophobicity of hydrogel that this property is due to presence of PNIPAAm in different temperatures. These unique properties of the hydrogel would make it a promising support for drug delivery systems and tissue regeneration.

Thermo-sensitive hydrogel; Polyvenylalcohol; Chitosan; N-Isopropylacrylamide; Gamma radiation

[ View HTML Full Text]