Abstract

Interpenetrating Network Polymer Hydrogels of Sodium Alginate and Poly(acrylic acid) for Controlled Release of Prazosin Hydrochloride

Hossein Hosseinzadeh

Abstract:

In this study, a novel interpenetrating polymer network (IPN) hydrogel composed of crosslinked sodium alginate and poly(acryl acid) was prepared for transdermal delivery of an anti-hypertensive drug, prazosin hydrochloride. Due to the reversible swelling behavior of the hydrogels, the synthesized networks can sense the environmental pH change and achieve an oscillatory release pattern. Using drug prazosin hydrochloride as a model molecule, the in vitro controlled drug-release behaviors of these hydrogels were investigated.

Keywords:

sodium alginate; acrylic acid; drug delivery; interpenetrating network polymer

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