Abstract

E. Dadapeer, S. Subba Reddy, V. Koteswara Rao and C. Naga Raju*

The schiff’s bases were prepared by reacting vaniline (4-hydroxy-3-methoxy benzaldehyde) with substituted aromatic amines in refluxing toluene. Dialkyl / diaryl phosphite undergoes addition readily with aromatic Schiff’s bases to give a-aminophosphonates (Pudovik reaction) in presence of catalytic amount of tetramethyl guanidine. The structures of the title compounds were established by elemental analysis, IR, 1H, 13C, 31P NMR and LCMS mass spectral data. The anti-microbial activities of these compounds were evaluated and they exhibited significant antimicrobial activity.

Aromatic Schiff’s bases; dialkyl/diaryl phosphite; tetramethyl guanidine; anti-microbial activity

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