Abstract

Gangadhar Shaw, G. M. Sreenivasa and E. Jayachandran

Various substituted 2[5'-(3-Methyl benzene)-1',3',4-thiadiazol-2'-yl amino)-6-flouro-7substituted (1,3) benzothiazoles and 2[5'-(p-chlorobenzene)-1',3',4'-thiadiazole-2'-yl amino) -6-fluoro-7substituted (1,3) benzothiazole containing different functional groups have been synthesized by condensing hydrazine hydrate with substituted 2-aminobenzothiazole in presence of ammonia, carban disulphide with ethanol and sodium chloroacetate. Further it is treated with various aromatic acid (p-chloro benzoic acid and 3-methyl benzoic acid) in presence of pyridine. The identity of compounds were confirmed on the basis of their spectral (UV, IR, 1H NMR and MASS) data. Further, they have been screened for their antimicrobial, anti-inflammatory and anticonvulsant activities.

Fluorine; Benzothiazole; Thiadiazole; anti-microbial

[ View HTML Full Text]