ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Three Component Solvent-Free Synthesis and Fungicidal Activity of Substituted Pyrimido [4,5-D] Pyrimidine-2-(1h)-One

Sandeep V. Shinde1*, Wamanrao N. Jadhav1 And Nandkisohr N. Karade2


Abstract:

A novel three component condensation of aromatic aldehyde, urea or thiourea and barbituric acid or N,N-1,3-dimethylbarbituric acid was carried out using L-proline as an organo-catalyst under solvent-free microwave conditions. The resulting product, pyrimido [4,5-d] pyrimidine-2-(1H)-one was checked for the fungicide activity.

Keywords:

Fungicidal acitivity; aromatic aldehyde

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