ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Synthesis and Characterization of 4-{4-(2-Methyl-4-Benzylidene-5-Oxo-Imidazol- 1-Yl)Phenyl}-6- (Substitutedphenyl)-5,6-Dihydropyrimidin-2-one and Study of their Antimicrobial Actvities

P. S. Patel1*, R. A. Shah2, D.K. Trivedi2 and P.J. Vyas1


Abstract:

4-{4-(2-methyl-4-benzylidene-5-oxo-imidazol-1-yl)phenyl}-6-(substitutedphenyl)-5,6-dihydropyrimidin-2-one have been prepared by the refluxation for 3 hours of 4-benzylidene-1-{4-[3-(substitutedphenyl)prop-2-enoyl]phenyl}-2-methyl-imidazol-5-one with urea and potassium hydroxide in presence of ethanol . The intermidiate 4-benzylidene-1-{4-[3-(substitutedphenyl)prop-2-enoyl]phenyl}-2-methyl-imidazol-5-one synthesized by the condensation of 1-(4-acetylphenyl)-4-benzylidene-2-methyl-3,5-dihydro-imidazol-5-one with various aldehydes.

Keywords:

Synthesis; substituted chalcones; dihydropyrimidin

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