Abstract

Zeinab Pourghobadi, Ali Niazi ^*

DOI : http://dx.doi.org/10.13005/ojc/300126

In this study, describes the voltammetric oxidation and determination of phenylephrine (PHE) hydrochloride at a new chemically modified electrode. Iron nanoparticle (INPs) was dispersed in Nafion solution to obtain a INP-Nafion-modified CPE for the voltammetric analysis of PHE .The electrochemical behaviour of PHE on INP-Nafion-modified CPE was studied, using cyclic voltammetry as a diagnostic technique. The effects of amount of INPs-Nafion dispersion, pH, and scan rate on the response of modified electrode for the oxidation of PHE were investigated. Using differential pulse voltammetry (DPV), the modified electrode indicated a dynamic linear range for quantitative determination of PHE in the range of 5 μM−130 μM, and the detection limit was estimated to be 0.76 μM. The method was developed for the determination of PHE in pharmaceutical samples with satisfactory results.

Phenylephrine Hydrochloride; Differential Pulse Voltammetry; Determination; Iron nanoparticles; Modified electrodes; Nafion.

[ View HTML Full Text]