Abstract

G. Mubeen*, Vaneeta Prakash and Kadri Uvesh

Two simple, precise and accurate colorimetric methods have been developed and validated for determination of Ornidazole in bulk and tablet formulation. These methods involves formation of complex diazonium salt of reduced Ornidazole with Metacresol reagent and Resorcinol reagent which shows absorption maxima (lmax) at 425 nm and 435 nm respectively. The linearity was observed in the concentration range of 5-40 μg/mL and 8-20 μg/mL for method A and method B respectively. The assay result was found to be in good agreement with label claim. The recovery studies were carried out at three different levels. The methods were validated statistically and by recovery studies and they were found to be accurate, precise and reproducible for determination of Ornidazole in bulk and solid dosage form.

Ornidazole; Colorimetry; Validation

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