ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Studies on Synthesis and Antibacterial Activity of Some New 3-(2-Hydroxyphenyl)-4-Benzoyl-5-Phenylisoxazolines

Madhuri P. Bhise1, V. M. Raut2, R. P. Pawar2, D. P. Gulwade2 and N. A. Junghare2


Abstract:

3-Aroyl flavanones (1a-j) were allowed to react with NH2 OH- HCl in dioxane containing piperidine to give the corresponding 3-(2-hydroxyphenyl)-4-aroyl-5-arylisoxazolines (2a-j). There structural assignment are based on the elemental analysis, spectra data (IR, UV & NMR) and chemical properties. All these compounds were tested in vitro for their antibacterial activity by disk-diffusion method against Gram positive and Gram negative bacterials. In some of the compounds the results are found to be encouraging.

Keywords:

3-(2-Hydroxyphenyl)-4-royl-5-arylixosazoline; antibacterial activity

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