Abstract

B. K. Magare¹, M. N. Farooqui², R. S. Shelke³ and M. B. Ubale^4*

Stability constant of some transition metals like Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes with pyrazinamide, isoniazid and ethambutol-HCl (22’-(1,2-Ethane dihydiimino)-bis-1-butanol) etb ,an antibacterial drugs have been evaluated at 30 o C & fixed 0.1 M (NaClO4 ) ionic strength in aqueous medium pH metrically . Proton ligand stability constants & metal ligand stability constants were determined by using Calvin Bjerrum titration technique as modified by Irving & Rossoti. Stability constants were discussed in terms of order of stability, basicity of ligands & correlated with atomic , ionization potential, electronegativity and reciprocal of ionic radii.

Stability constant; ligands; ionic strength; basicity; antibacterial drugs etc

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