Abstract

Samia Benhammadi, Salimairaten  and Adil A. Othman

DOI : http://dx.doi.org/10.13005/ojc/320528

A series of S-glucosides11a-14a and their benzamido derivatives 11b-14b have been synthesized by reacting D-glucose withthiol groups of 5-(2’-aminophenylene)-1,3,4-oxadiazole-2-thioles7(a,b), 5-(2’-aminophenylene)-1,3,4-thiadiazole-2-thiols8(a,b), 5-(2’-aminophenylene)-1,2,4-triazole-3-thiols9(a,b)and 5-(2’-aminophenylene)-4-N-amino-1,2,4-triazole-3-thiols10(a,b). The thiols7(a,b)-10(a,b) have been synthesized from hydrazides3(a,b)which already been synthesized from 2-aminobenzoic acid and its benzamido derivative.Allsynthesized compoundswerecharacterized by IR, UV,¹H- and¹³C- NMR. Nucleobases and a representative of S-glycoside weretestedin vitro against the following microorganisms: twoGram-positive bacteria Staphylococcus aureusandBacillus cereusand two Gram-negative bacteria Escherichia coli, Pseudomonasaeruginosaand they exhibited significant effects.Amykacinewas used as positive standard.

Nucleobases; glycosides; benzamide derivatives; synthesis; antibacterial activity

[ View HTML Full Text]