ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

An Efficient and Novel Regioselective Synthesis of Phosphonylpyrazoles from Vinylazides and Bestmann-Ohira Reagent

>Aravinda Kumar Madugula1, Vaithiyanathan Mahendran2, Ajjanna Mahalingappa Sridhara3 and Gururaja Rangaiah1*

DOI : http://dx.doi.org/10.13005/ojc/320524


Abstract:

A novel and efficient reaction of vinyl azides with Bestmann-Ohira reagent for the regioselective synthesis of phosphonylpyrazoles is presented. Reaction proceeds through 1, 3 dipolar cycloaddition with an excellent yield in short period of time under mild reaction conditions. Moreover, no column purification is involved for the isolation of products.

Keywords:

Phosphonylpyrazoles; Vinylazides; 1,3-dipolar cycloaddition; regioselectivity; Bestmann-Ohira reagent

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