Abstract

Faiz Mohd. Abdullah^* and Arvind Kumar Singh

DOI : http://dx.doi.org/10.13005/ojc/290231

Certain N-1 substituted fluoroquinolonic derivatives were synthesized and evaluated for antimicrobial and antioxidant activities. N-1 alkyl/ aryl/ aryl sulphonyl substituted derivatives of the title compounds have been synthesized to identify newer fluoroquinolones which have better efficacy, lesser side effects and well tolerability. The biological evaluation of the synthesized fluoroquinolone derivatives was carried out using agar-well diffusion method and compounds FI-ETH, FII-SUL, FIII-ATY, FIV-BZO, and FV-BZY were found to be active against both Gram-positive and Gram-negative bacteria having activity comparable to that of standard drug i.e. Ofloxacin 10mg/ml. N-1 substituted moiety is mostly active against strain is S. aureus, K. Pneumonia, and E. coli with concentration of 100 - 150μg/ml, and less active against strain is B. subtilis. And secondly, antioxidant activity is that of show the better activity by this four method DPPH Free Radical Scavenging Assay, Hydrogen Peroxide Radical Scavenging Activity, Nitric Oxide Assay, and Reducing Power Assay. All the synthesized compounds show the better antioxidant activity and in fourth one method result is mostly capable reducing power activity of the synthesized compounds.

Fluoroquinolones; Antibacterials; Antioxidant agent

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