Abstract

Nuanchai Khotsaeng, Kansiri Pakkethati and Yodthong Baimark

DOI : http://dx.doi.org/10.13005/ojc/320503

In this work, the effect ofL-lactide (LL)copolymerization on the properties of poly(D,L-lactide) (PDLL) and poly(D,L-lactide-co-glycolide) (PDLLG)copolymers and its drug release behaviors were determined and discussed.The copolymers were synthesized by ring-opening polymerization of DLL, LL, and G monomer mixtures. The PDLL with DLL/LL ratios of 100/0-50/50 by mole and the PDLLG with DLL/LL/G ratios of 75/0/25-37.5/37.5/25 by mole were investigated. All the copolymers were completely amorphous.The drug-loadedcopolymer microparticles with a spherical shape and smooth surfacewere prepared by the oil-in-water emulsion solvent evaporation method.Indomethacin was used as a poorly-water soluble model drug.The copolymerization of the LL monomer did not change thein vitro drug release profiles of the PDLL and the PDLLG microparticles significantly.It is suggested that theseamorphous PDLL and PDLLG copolymersthat containhigher L enantiomer amounts have the potential to be developed further as a lower-cost PDLL and PDLLG, respectively,for use as controlled release drug delivery systems.

Lactide; Glycolide; Copolymers; Microparticles; Drug delivery

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