Abstract

Mohammad Sadeghi^*, Fatemeh Shafiei And Esmat Mohammadinasab

DOI : http://dx.doi.org/10.13005/ojc/300136

To following synthesis of a novel alginte-based composite superabsorbent hydrogel was through crosslinking graft copolymerization of acrylic acid onto alginate in presence kaolin, we investigated the usefulness of a pH-sensitive protein-based hydrogel for in vitro controlled release of cefalexin. The loading drug yield was found to depend on the incubation time, the amount of encapsulated drug. In addition, the release of cefalexin from this kind of hydrogel was studied. The release rate of cefalexin from hydrogel at pH 7.4 was faster than that at pH 1.6 due to the shrinkage of the hydrogel at pH 1.6.

alginte; releasing drug; hydrogels; composite; cefalexin.

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