Abstract

Swamy Saidugari^1,2,Lakshmana Rao Vadali¹, Vidya K² and Ram B³

DOI : http://dx.doi.org/10.13005/ojc/320445

The synthesis of novel 1,2,3-triazole-hydrazone derivatives embedded with 3,4-dimethoxy pyridine ring nucleus is described. These derivatives were prepared utilizing, 2-(chloromethyl)-3,4-dimethoxypyridine 1, 4-ethynylbenzaldehye 5 and various benzohydrazides7a-7j. The structures of the newly synthesized 1,2,3-triazole-hydrazones 8a-j was established on the basis of the spectroscopic techniques like ¹H NMR, mass and IR data. They were evaluated against a panel of bacterial and fungal pathogens such as Staphylococcus. pyogens, Staphylococcus. aureus (Gram positive bacteria), Escherichia.coli, Pseudomonas. aeruginosa(Gram negative bacteria) and Aspergillus niger and candida albicans(Fungal stains).Compounds 8b, 8c, 8d, 8e and 8f with R = 4-OH, 4-OMe, 4-SO₂Me, 3,4,5,-OMe and 3-NO₂ respectively showed moderate antibacterial activity while compounds 8b, 8d, 8i and 8j with R = 4-OH, 4-SO2Me,  3,5-dichloro and 2,5-difluoro substitution exhibited very good fungal activity

1,2,3-triazole; Hydrazone; 4-ethynylbenzaldehyde; Synthesis; Antifungal activity

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