Abstract

P. K. Dwivedi, B. K. Dubey and I. C. Shukla*

A simple and convenient method has been developed for the milligram determination of some ophthalmic drugs e.g. Oxymetazoline hydrochloride, Lignocane hydrochloride, Prednisolone acetate, Chloramphenicol, Potassium Iodide, Benzocaine, Ofloxacin and Sulphacetamide sodium in pure form and in their pharmaceutical preparations. Aliquots (1-5 mg) of the samples are allowed to react with 0.3 N ammonium meta vanadate reagent in acidic medium for required reaction time at boiling water bath. After the reaction is over, the unconsumed reagent is back determined by titration against ferrous ammonium sulphate using N-phenyl anthranilic acid indicator. The value of percentage error, SD and CV prove the method to be precise and reproducible.

Ophthalmic drugs; Pharmaceutical; ammonium metavandate

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