Abstract
Synthesis of New 2,3 Disubstituted Quinoxalines from 2'-Hydroxy-4'- Methyl-5'-Chloro-4-Substituted Chalcones
C. K. Patil and A. G. Doshi
Abstract:
2'-Hydroxy-4'-methyl-5'-chloro-4-methoxy chalcone (Ia), 2'-hydroxy-4'-methyl-5'-chloro chalcone (Ib), 2'-hydroxy-4'-methyl-5'-chloro-4 chloro chalcone (Ic) and 2'-hydroxy-4'-methyl-5-chloro-4-dimethyl amino chalcone (Id) reacts with bromine n acetic acid gives chalcone dibromides (II a-d). The chalcone dibromide (II a-d) condenses with Benzene 1,2-diamine (BDA) in presence of few drops of concentrated H2SO4 in methanol medium affords 2-(2'-hydroxy-4'-methyl-5'-chloro) benzyl-3-(4-substituted phenyl)-quinoxaline (III a-d). The structure of these compounds were confirmed by analytical and spectral data."
Keywords:Substituted quinoxalines; Chalcones
Back to TOC