ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract

Synthesis of New 2,3 Disubstituted Quinoxalines from 2'-Hydroxy-4'- Methyl-5'-Chloro-4-Substituted Chalcones

C. K. Patil and A. G. Doshi


Abstract:

2'-Hydroxy-4'-methyl-5'-chloro-4-methoxy chalcone (Ia), 2'-hydroxy-4'-methyl-5'-chloro chalcone (Ib), 2'-hydroxy-4'-methyl-5'-chloro-4 chloro chalcone (Ic) and 2'-hydroxy-4'-methyl-5-chloro-4-dimethyl amino chalcone (Id) reacts with bromine n acetic acid gives chalcone dibromides (II a-d). The chalcone dibromide (II a-d) condenses with Benzene 1,2-diamine (BDA) in presence of few drops of concentrated H2SO4 in methanol medium affords 2-(2'-hydroxy-4'-methyl-5'-chloro) benzyl-3-(4-substituted phenyl)-quinoxaline (III a-d). The structure of these compounds were confirmed by analytical and spectral data."

Keywords:

Substituted quinoxalines; Chalcones

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