Abstract

George Jacob

DOI : http://dx.doi.org/10.13005/ojc/290410

The synthesis and characterization of Zinc complex with glimepiride (an oral antidiabetic drug) has been studied. The conductometric titration using monovariation method indicates that complex is non-ionic and of ML₂ type. Analytical data agrees with the molecular formula (C₂₄H₃₄N₄O₅S)₂ Zn. Structure of the complex was assigned as tetrahedral in which ligand molecules lies horizontally joining the central zinc atom. IR, NMR, Mass spectral and X-ray studies confirm the co-ordination of sulphonyloxygen on one side and enolic oxygen attached from other side with the metal ion. Tentative structure for complex was proposed on the basis of analytical data and Elemental analysis.

Synthesis; Characterization; Glimepiride-metal ion complex; Infrared spectroscopy

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