Abstract

S. Kulathooran¹, T. Vadivel¹, M. Dhamodaran^2* and B. Selvakumar³

DOI : http://dx.doi.org/10.13005/ojc/320232

A series of some new 1-thiocarbamoyl-3-(2,5-dimethylfuran-3-yl)-5-(fluoro/trifluoromethylphenyl)-2-pyrazolines 4a-f have been synthesized by treating with various fluoro/trifluoromethyl substituted chalcones, thiosemicarbazide and potassium carbonate using conventional heating and solvent-free microwave irradiation techniques. The easy work-up of the products, rapid reaction and mild conditions are noticeable features of this protocol. Synthesized compounds have been screened for their in vitro antimicrobial activity against six microbial strains. Among them, 1-Thiocarbamoyl-3-(2,5-dimethylfuran-3-yl)-5-(3-fluorophenyl)-2-pyrazoline 4b showed maximum zone of inhibition against all the tested microorganisms. Structural elucidation of the synthesized compounds were determined on the basis of various spectroscopic methods.

Microwave solvent-free reaction; Solid-phase synthesis; Chalcones; Pyrazolines; Antimicrobial activity

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