Abstract

Amel Bendjeddou^1,*, Tahar Abbaz^1,3, Adel Ayari¹, Merzoug Benahmed², Abdelkrim Gouasmia³ and Didier Villemin⁴

DOI : http://dx.doi.org/10.13005/ojc/320205

In the present study a series of unsymmetric linear sulfamides (1-9) starting from a primary amine were synthesized and their structures were confirmed by elemental analyses, mass spectrometry and ¹H NMR techniques. All the synthesized compounds were screened for their antibacterial activities by both disc diffusion and minimal inhibition concentration (MIC) methods. Frontier molecular orbital (FMO) analysis and global reactivity descriptors have been performed using the density functional theory (DFT) with the B3LYP functional. The results indicated that these derivatives, depending of their substituted radical, bring about an improvement in the bacterial activity.

Unsymmetric sulfamides; Antibacterial activity; global reactivity; Minimum inhibitory concentrations (MIC)

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