Abstract
Synthesis, Characterization and Spectral Study of Zinc Complex with Gliclazide( N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4- methylbenzenesulfonamide) and its Hypoglycemic Activity
Bal Krishan*1 and Ishaq Zaafarany2
DOI : http://dx.doi.org/10.13005/ojc/290439
Abstract:
The present paper describes Synthesis and characterization, spectral, x-Ray and hypoglycemic activity studies of zinc complex with gliclazide, an oral antidiabetic drug. The conductometric titration using monovariation method indicate that complexes are non-ionic and L2M type. Analytical data agrees with the molecular formula (C15H20N3O3S)2Zn. Structure of complex was assigned tetrahedral for zinc, supported by IR, X-Ray. Structure (I) is proposed for complex. Alloxan induced model was used to compare the hypoglycemic activity and found that zinc complex of gliclazide is more potent than parent drug.
Keywords:Gliclazide;sulphonylurea;complex; IR;X-Ray;hypoglycemic activity
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