Abstract

Abdullah Saad Albogami, Usama Karama, Ahmed Amine Mousa, M. Khan, Sara Abdullah Al-Mazroa and Hamad Z. Alkhathlan*

A facile and highly efficient microwave-assisted synthesis of functionalized chalcones and flavanones based on the Claisen-Schmidt condensation reaction is reported. The method describes the synthesis of flavanones in single step with excellent yield and it was revealed that position and number of substituents on acetophenones and aromatic aldehydes played a very crucial and key role in the construction of flavanone derivatives. Among the thirty two synthesized compounds, five chalcones and one flavanone were novel compounds.

Flavanones; 2'-Hydroxyachalcones; Microwave Irradiation; Claisen-Schmidt Condensation

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