Abstract

Gajraj Sharma, G.M. Sreenivasa and E. Jayachandran*

Various substituted 3-{6-fluoro-7-(substituted)-1,3-benzothiazol-2-yl-1-[(4-acetyl-5-methyl-5- phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-2-thioxo-2,3-dihydroquinazoline-4 (1H) -one and 3-{(6- fluoro –7- (substituted) - 1,3 -benzothiazol-2-yl-1-({4-acetyl-5-[4-(dimethylamino)phenyl]-4,5-dihydro- 1,3,4-oxadiazol-2-yl}methyl) -2- thioxo -2,3- dihydroquinazolin –4 (1H)-one. containing different functional groups have been synthesized by condensing anthranilic acids with substituted 2-aminobenzothiazoles in dry pyridine and then by condensing with ethylchloroacetate in presence dry acetone and K2CO3. The identity of compounds were confirmed on the basis of their spectral (UV, IR, 1 H NMR and MASS) data. Further, they have been screened for their antimicrobial activities.

Fluorine; benzothiazole; quinazoline (Cyclo addition reaction) Oxadizole (Schiff base)

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