Abstract

Md. Sahidul Islam, Roksana Khatun^* and Antika Das Gupta

DOI : http://dx.doi.org/10.13005/ojc/400323

The effect of NaCl and KCl on the micellization of sodium dodecyl sulfate (SDS) and sodium dodecyl benzene sulfonate (SDBS) surfactants in cephradine monohydrate (CPDM) has been studied by conductance measurement. In this study, we have examined the critical micelle concentration (CMC) of surfactant solutions in drug-salt systems by conductance measurement in an aqueous medium and electrolyte solutions. In this study, CMC were calculated through piece-wise linear model by identifying a distinct and abrupt change in the specific conductivity (G) as the surfactant concentration increased. In all the experimental cases examined, a single CMC was identified for both the CPDM + SDS and CPDM + SDBS systems. The presence of CPDM in an aqueous solution decreases the critical micelle concentration (CMC) of surfactants, thereby increasing the degree of micellization. The CMC values were found to favorable with an increase of salt NaCl and KCl concentrations. And very tremendously different results were found between CPDM + SDS/SDBS and CPDM + SDS/SDBS+KCl and CPDM + SDS/SDBS+NaCl systems. The result shows very remarkable information about the micellization of surfactants in the presence of drug and salt solutions

CMC; Micelle; Micelle ionization Value; Specific Conductivity

[ View HTML Full Text]