Abstract

Rojin Biro Haji^*, Maher Khalid Ali, Shireen Rashid Mohammed

DOI : http://dx.doi.org/10.13005/ojc/390508

Over three major convenient steps, a series of some novel Bis-Schiff bases, and Bis 1,3-thiazolidin-4-one derivatives have been synthesized: Firstly, the etherification process through the reaction of the 4-hydroxybenzaldehyde substrate with o-, m-, and p-chlorobenzylchlorides under mild circumstances. Secondly, the condensation reaction between 4-((chlorobenzyl)oxy)benzaldehyde compounds with a number of aromatic diamines in an acidic environment produces the required Bis-Schiff intermediates. Finally, the practical cyclization step was finished by synthesizing the required Bis 1,3-thiazolidin-4-one products with 79-97% yields through refluxing reaction in benzene with thioglycolic acid.

Bis-Schiff bases; Cyclization Process; 4-((chlorobenzyl)oxy)benzaldehyde; Etherification process; heterocyclic compounds; Thioglycolic Acid; 1,3-thiazolidin-4-ones;

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