Abstract

Siva Sanker Reddy Lingareddygari^*, Nageswara Rao Ravikrindhi, Madana Gopal Nookala, Shaik Muneer, Prasad Nakka

DOI : http://dx.doi.org/10.13005/ojc/390430

RP-HPLC method developed is a simple, precise and functional technique for the calculation of amount of Quetiapine fumarate from marketed tablets and bulk form. The RP-HPLC analysis was carried out on Hyper chrome ODS-BP 5µm column (4.6mm × 200mm) using a mobile phase 0.1% Orthophoshoric acid and Acetonitrile (80:20v/v) with pH 5.5. Quetiapine fumarate quantified by using UV detector at 210nm. The retention time of the Quetiapine fumarate was found to be 2.6 min. The linearity of the drug concentration ranges from 20-400µg/ml. The detection and quantification limits were intended at 3.70µg/ml and 12.35µg/ml. The precision, accuracy, specificity, robustness and degradation studies were validated.

Acetonitrile; 0.1% Orthophoshoric acid; Quetiapine fumarate; RP-HPLC; Validation

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